humanpred

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• `pk.calc.time_above()` with lin-up/log-down silently drops segments that end at a negative value

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  Difficulty 2/5 1-3 hours Newbie friendliness 79/100

  humanpred/pknca#697 · Opened Oct 28, 2026

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• `pk.calc.aucabove()` (and so `aucabove.predose.all` and `aucabove.trough.all`) is biased at threshold crossings and with lin-up/log-down

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  Difficulty 4/5 3-5 days Newbie friendliness 45/100

  humanpred/pknca#696 · Opened Oct 28, 2026

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• `ceoi` errors when an interval has more than one dose row

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  Difficulty 3/5 1-2 days Newbie friendliness 67/100

  humanpred/pknca#695 · Opened Oct 28, 2026

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• `mrt.iv.*`, `mrt.md.iv.*` and `vss.iv*` are wrong (and duplicated) when an interval has more than one infusion dose row

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  Difficulty 4/5 3-5 days Newbie friendliness 58/100

  humanpred/pknca#694 · Opened Oct 28, 2026

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• Join COSA

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  Difficulty 5/5 Over a week Newbie friendliness 10/100

  humanpred/pknca#393 · 2 comments · Opened Feb 16, 2025

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• Feature request: SDTM input functions

  Possibly taken @Gero1999 claimed this 227 days ago. Open

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  Difficulty 4/5 3-5 days Newbie friendliness 20/100

  humanpred/pknca#516 · 2 comments · Opened Mar 16, 2026

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• Feature request: New logslope & c1 impute_start methods

  Possibly taken @Gero1999 claimed this 633 days ago. Open

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  Difficulty 3/5 1-2 days Newbie friendliness 20/100

  humanpred/pknca#350 · 3 comments · Opened Jan 3, 2025

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