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Cython bindings and Python interface to CoMSA, a compressor for multiple-sequence alignments.

Last commit Mar 25, 2026

 (2 stars) (0 forks) (0 indexed issues) (0 open good first issues)

Cython bindings and Python interface to FAMSA, an algorithm for ultra-scale multiple sequence alignments.

Last commit Mar 24, 2026

 (43 stars) (4 forks) (0 indexed issues) (0 open good first issues)

Cython bindings and Python interface to FastANI, a method for fast whole-genome similarity estimation.

Last commit Mar 7, 2026

 (24 stars) (2 forks) (0 indexed issues) (0 open good first issues)

A hidden conditional random field (HCRF) implementation in Python.

Last commit Nov 10, 2020

 (3 stars) (1 fork) (0 indexed issues) (0 open good first issues)

Cython bindings and Python interface to HMMER3.

Last commit May 27, 2026

 (164 stars) (17 forks) (0 indexed issues) (0 open good first issues)

Cython bindings and Python interface to Infernal 1.1.

Last commit Mar 31, 2026

 (9 stars) (0 forks) (0 indexed issues) (0 open good first issues)

Cython bindings and Python interface to Jess, a 3D template matching software for protein structures. Now 10x faster!

Last commit May 27, 2026

 (11 stars) (0 forks) (0 indexed issues) (0 open good first issues)

Cython bindings and Python interface to the MEME suite, a collection of tools for the analysis of sequence motifs.

Last commit Mar 7, 2026

 (17 stars) (0 forks) (0 indexed issues) (0 open good first issues)

Cython bindings and Python interface to MUSCLE v5, a highly efficient and accurate multiple sequence alignment software.

Last commit Mar 7, 2026

 (25 stars) (2 forks) (0 indexed issues) (0 open good first issues)

Cython bindings and Python interface to the NCBI C++ ToolKit (including BLAST+).

Last commit Jun 3, 2026

 (11 stars) (0 forks) (0 indexed issues) (0 open good first issues)

Cython bindings and Python interface to Opal, a SIMD-accelerated database search aligner.

Last commit Mar 25, 2026

 (11 stars) (1 fork) (0 indexed issues) (0 open good first issues)

A Python implementation of the OrthoANI algorithm for nucleotide identity measurement.

Last commit Jul 21, 2025

 (36 stars) (4 forks) (0 indexed issues) (0 open good first issues)

Cython bindings and Python interface to PhyML 3.

Last commit Dec 15, 2025

 (0 stars) (0 forks) (0 indexed issues) (0 open good first issues)

Cython bindings and Python interface to Prodigal, an ORF finder for genomes and metagenomes. Now with SIMD!

Last commit Mar 17, 2026

 (189 stars) (10 forks) (0 indexed issues) (0 open good first issues)

A Pyrodigal extension to predict genes in giant viruses and viruses with alternative genetic code.

Last commit Nov 25, 2025

 (23 stars) (4 forks) (0 indexed issues) (0 open good first issues)

Pysam is a Python package for reading, manipulating, and writing genomics data such as SAM/BAM/CRAM and VCF/BCF files. It's a lightweight wrapper of the HTSlib API, the same one that powers samtools, bcftools, and tabix.

Last commit Mar 26, 2025

 (0 stars) (0 forks) (0 indexed issues) (0 open good first issues)

PyO3 bindings and Python interface to skani, a method for fast genomic identity calculation using sparse chaining.

Last commit Aug 20, 2025

 (29 stars) (2 forks) (0 indexed issues) (0 open good first issues)

Cython bindings and Python interface to SWORD (Smith Waterman On Reduced Database), a heuristic method for fast database search.

Last commit Mar 7, 2026

 (5 stars) (0 forks) (0 indexed issues) (0 open good first issues)

PyO3 bindings and Python interface to sylph, an ultrafast method for containment ANI querying and taxonomic profiling.

Last commit Nov 6, 2024

 (21 stars) (0 forks) (0 indexed issues) (0 open good first issues)

Cython bindings and Python interface to Tantan, a fast method for identifying repeats in DNA and protein sequences.

Last commit Apr 21, 2026

 (3 stars) (1 fork) (0 indexed issues) (0 open good first issues)