Opening-Science

Issues somebody may already be working on are listed last. List everything by date

• Genome variants for imported VCF without Carbon-X

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  Difficulty 3/5 1-2 days Newbie friendliness 65/100

  Opening-Science/twin-llm#330 · Opened Oct 30, 2026

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• Make decline wording W3 the chat default

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  Difficulty 2/5 1-3 hours Newbie friendliness 78/100

  Opening-Science/twin-llm#329 · Opened Oct 30, 2026

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• Import routes test fails intermittently in the full suite

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  Difficulty 3/5 Half a day Newbie friendliness 58/100

  Opening-Science/twin-llm#324 · Opened Oct 30, 2026

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• Heart-brain: explain the post-onset stroke excess against the oracle

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  Difficulty 4/5 3-5 days Newbie friendliness 35/100

  Opening-Science/twin-llm#323 · Opened Oct 30, 2026

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• Eval: a fair data-in-prompt arm without key-chosen rows

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  Difficulty 4/5 3-5 days Newbie friendliness 38/100

  Opening-Science/twin-llm#320 · Opened Oct 30, 2026

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• UI: interaction patterns that show what the app is doing

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  Difficulty 4/5 3-5 days Newbie friendliness 48/100

  Opening-Science/twin-llm#310 · Opened Oct 30, 2026

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• Fine-tune pilot 2: held-out templates and more no-data cases

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  Difficulty 4/5 3-5 days Newbie friendliness 43/100

  Opening-Science/twin-llm#305 · Opened Oct 30, 2026

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• Eval: held-out S1 to S6 items and a small human review

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  Difficulty 5/5 Over a week Newbie friendliness 20/100

  Opening-Science/twin-llm#304 · Opened Oct 30, 2026

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• Eval: a code-writing arm in a sandbox

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  Difficulty 4/5 3-5 days Newbie friendliness 38/100

  Opening-Science/twin-llm#303 · Opened Oct 30, 2026

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• Eval: a data-in-prompt arm

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  Difficulty 3/5 1-2 days Newbie friendliness 45/100

  Opening-Science/twin-llm#302 · Opened Oct 30, 2026

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• Disclosure experiment: a positive control and attacks on the served model

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  Difficulty 5/5 Over a week Newbie friendliness 20/100

  Opening-Science/twin-llm#301 · Opened Oct 30, 2026

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• Audit chain: an external anchor for the head hash

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  Difficulty 5/5 Over a week Newbie friendliness 20/100

  Opening-Science/twin-llm#300 · Opened Oct 30, 2026

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• Rhythm simulator: AF intervals with realistic dependence

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  Difficulty 4/5 3-5 days Newbie friendliness 52/100

  Opening-Science/twin-llm#297 · Opened Oct 30, 2026

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• Heart-brain: full-history batches and a rule-change test

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  Difficulty 3/5 1-2 days Newbie friendliness 45/100

  Opening-Science/twin-llm#295 · Opened Oct 30, 2026

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• Heart-brain: the language-model arm

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  Difficulty 4/5 3-5 days Newbie friendliness 52/100

  Opening-Science/twin-llm#293 · Opened Oct 30, 2026

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• Rhythm: how much AF signal survives from beats to daily summaries

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  Difficulty 5/5 Over a week Newbie friendliness 25/100

  Opening-Science/twin-llm#290 · Opened Oct 30, 2026

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• Models answer rhythm 'do I have AF' questions instead of declining

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  Difficulty 3/5 1-2 days Newbie friendliness 72/100

  Opening-Science/twin-llm#274 · Opened Oct 30, 2026

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• Eval: S4 needs GBD settings in the eval env

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  Difficulty 2/5 1-3 hours Newbie friendliness 48/100

  Opening-Science/twin-llm#273 · Opened Oct 30, 2026

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• Rhythm benchmark on an AF database independent of the thresholds

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  Difficulty 4/5 3-5 days Newbie friendliness 35/100

  Opening-Science/twin-llm#264 · Opened Oct 29, 2026

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• Explicit consent before any learning from personal data

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  Difficulty 5/5 Over a week Newbie friendliness 38/100

  Opening-Science/twin-llm#145 · Opened Oct 27, 2026

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• Harden local storage against other programs

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  Difficulty 5/5 Over a week Newbie friendliness 35/100

  Opening-Science/twin-llm#144 · Opened Oct 27, 2026

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• Audit every read of personal data, not only model tool reads

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  Difficulty 4/5 3-5 days Newbie friendliness 38/100

  Opening-Science/twin-llm#143 · 1 comment · Opened Oct 27, 2026

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• Local unlock before personal data can be read

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  Difficulty 5/5 Over a week Newbie friendliness 25/100

  Opening-Science/twin-llm#142 · Opened Oct 27, 2026

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• Encrypt personal data at rest

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  Difficulty 5/5 Over a week Newbie friendliness 25/100

  Opening-Science/twin-llm#141 · Opened Oct 27, 2026

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• Disclosure ledger: what left the machine, per recipient, cumulatively

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  Difficulty 5/5 Over a week Newbie friendliness 35/100

  Opening-Science/twin-llm#140 · Opened Oct 27, 2026

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• Background tasks panel and scheduled check-ins

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  enhancement ui

  Difficulty 5/5 Over a week Newbie friendliness 35/100

  Opening-Science/twin-llm#54 · Opened Oct 26, 2026

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• Heart-brain: an oracle for the planted AF-to-stroke effect

  Possibly taken @CPD9 claimed this 1 day ago. Open

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  Difficulty 4/5 3-5 days Newbie friendliness 35/100

  Opening-Science/twin-llm#294 · Opened Oct 30, 2026

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• Medical agents: GP, specialists, trainer, with auto mode

  Possibly taken A pull request linked to this issue is open or already merged. Open

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  Difficulty 5/5 Over a week Newbie friendliness 25/100

  Opening-Science/twin-llm#210 · 1 comment · Opened Oct 28, 2026

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• Live external knowledge sources (PubMed, Ensembl and others)

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  connectors enhancement help wanted

  Difficulty 5/5 Over a week Newbie friendliness 35/100

  Opening-Science/twin-llm#6 · 1 assignee · Opened Oct 25, 2026

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