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Cython bindings and Python interface to CoMSA, a compressor for multiple-sequence alignments.

Ultimo commit 25 mar 2026

 (2 star) (0 fork) (0 issue indicizzate) (0 good first issue aperte)

Cython bindings and Python interface to FAMSA, an algorithm for ultra-scale multiple sequence alignments.

Ultimo commit 24 mar 2026

 (46 star) (5 fork) (0 issue indicizzate) (0 good first issue aperte)

Cython bindings and Python interface to FastANI, a method for fast whole-genome similarity estimation.

Ultimo commit 22 lug 2026

 (25 star) (2 fork) (0 issue indicizzate) (0 good first issue aperte)

A hidden conditional random field (HCRF) implementation in Python.

Ultimo commit 10 nov 2020

 (3 star) (1 fork) (0 issue indicizzate) (0 good first issue aperte)

Cython bindings and Python interface to HMMER3.

Ultimo commit 13 ago 2026

 (168 star) (19 fork) (0 issue indicizzate) (0 good first issue aperte)

Cython bindings and Python interface to Infernal 1.1.

Ultimo commit 31 mar 2026

 (10 star) (0 fork) (0 issue indicizzate) (0 good first issue aperte)

Cython bindings and Python interface to Jess, a 3D template matching software for protein structures. Now 10x faster!

Ultimo commit 7 ago 2026

 (11 star) (0 fork) (0 issue indicizzate) (0 good first issue aperte)

Cython bindings and Python interface to the MEME suite, a collection of tools for the analysis of sequence motifs.

Ultimo commit 7 mar 2026

 (18 star) (0 fork) (0 issue indicizzate) (0 good first issue aperte)

Cython bindings and Python interface to MUSCLE v5, a highly efficient and accurate multiple sequence alignment software.

Ultimo commit 7 mar 2026

 (25 star) (2 fork) (0 issue indicizzate) (0 good first issue aperte)

Cython bindings and Python interface to the NCBI C++ ToolKit (including BLAST+).

Ultimo commit 2 ago 2026

 (11 star) (0 fork) (0 issue indicizzate) (0 good first issue aperte)

Cython bindings and Python interface to Opal, a SIMD-accelerated database search aligner.

Ultimo commit 25 mar 2026

 (11 star) (1 fork) (0 issue indicizzate) (0 good first issue aperte)

A Python implementation of the OrthoANI algorithm for nucleotide identity measurement.

Ultimo commit 21 lug 2025

 (37 star) (4 fork) (0 issue indicizzate) (0 good first issue aperte)

Cython bindings and Python interface to PhyML 3.

Ultimo commit 15 dic 2025

 (0 star) (0 fork) (0 issue indicizzate) (0 good first issue aperte)

Cython bindings and Python interface to Prodigal, an ORF finder for genomes and metagenomes. Now with SIMD!

Ultimo commit 17 mar 2026

 (189 star) (11 fork) (0 issue indicizzate) (0 good first issue aperte)

A Pyrodigal extension to predict genes in giant viruses and viruses with alternative genetic code.

Ultimo commit 25 nov 2025

 (24 star) (4 fork) (0 issue indicizzate) (0 good first issue aperte)

Pysam is a Python package for reading, manipulating, and writing genomics data such as SAM/BAM/CRAM and VCF/BCF files. It's a lightweight wrapper of the HTSlib API, the same one that powers samtools, bcftools, and tabix.

Ultimo commit 26 mar 2025

 (0 star) (0 fork) (0 issue indicizzate) (0 good first issue aperte)

PyO3 bindings and Python interface to skani, a method for fast genomic identity calculation using sparse chaining.

Ultimo commit 20 ago 2025

 (29 star) (2 fork) (0 issue indicizzate) (0 good first issue aperte)

Cython bindings and Python interface to SWORD (Smith Waterman On Reduced Database), a heuristic method for fast database search.

Ultimo commit 7 mar 2026

 (5 star) (0 fork) (0 issue indicizzate) (0 good first issue aperte)

PyO3 bindings and Python interface to sylph, an ultrafast method for containment ANI querying and taxonomic profiling.

Ultimo commit 6 nov 2024

 (20 star) (0 fork) (0 issue indicizzate) (0 good first issue aperte)

Cython bindings and Python interface to Tantan, a fast method for identifying repeats in DNA and protein sequences.

Ultimo commit 21 apr 2026

 (4 star) (1 fork) (0 issue indicizzate) (0 good first issue aperte)