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Double Ligand Enzyme

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#38 1 comment 0 reactions 0 assignees View on GitHub

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Assessment

Difficulty
5/5
Estimated time
Over a week
Newbie friendliness
20/100
Issue type
Feature
Clarity
Needs clarification
Activity status
Stale
Tech stack
python
Domain
bioinformatics, machine-learning

Research direction

No files, tests, or entry points are named. Start by reviewing the RFdiffusion paper and the repository's documented inference pipeline, then determine whether glycosyltransferase reactions with donor and acceptor substrates are in scope. Done would require an agreed pipeline, implementation scope, and validation criteria.

Written by the indexing model from the issue text.

Description

Hi, I have been reading the paper for RFDiffusion and realized that the reaction catalyzed by the enzymes designed (based on real examples) only use one substrate... I was wondering if you think it is possible to design an enzyme that requires both an acceptor and a donor substrate based on a real example of course, which will be a glycosyltransferase. What will be the pipeline in this case?

Dominant language
Python
Stars
443
Forks
70
No merged PRs in 30d

Contributor guide

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First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

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