OpenFreeEnergy/alchemiscale

Replace `nest_asyncio` if possible in `AlchemiscaleClient`

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#488 opened on Mar 11, 2026

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component-user-clientgood first issue

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Description

nest_asyncio appears to no longer be developed, and though it appears to work fine for now, it may be worth pursuing alternatives. We only use it in a couple AlchemiscaleClient methods that make use of asyncio, allowing them to be used in e.g. Jupyter notebooks without issues.

Contributor guide

Research direction
Research alternatives to nest asyncio for running asyncio in Jupyter notebooks, such as using asyncio.run() with proper event loop handling. Then implement the replacement in the AlchemiscaleClient methods, ensuring all tests pass.
Tech stack
python
Domain
backend
Issue type
Refactor
DifficultyEstimated implementation difficulty for a new contributor, from 1 for very small changes to 5 for expert-level work.
2
Estimated timeA rough time range for an experienced contributor to investigate, implement, test, and prepare a pull request.
1-3 hours
Activity statusHow available the issue appears right now: fresh, active, stale, blocked, or waiting on maintainer input.
Active
ClarityHow clearly the issue explains the expected change, acceptance criteria, and next step.
Clear
Prerequisites
Pythonasyncio
Newbie friendlinessA 1-100 score estimating how approachable this issue is for first-time contributors.
75